Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma
N Mitsuhashi, H Shimizu, M Ohtsuka, Y Wakabayashi… - Hepatology, 2003 - Elsevier
Human hepatocellular carcinoma (HCC) is a hypervascular tumor but the mechanisms
underlying the process of angiogenesis are not fully understood. Angiopoietins (Ang) have
been recently identified as ligands for Tie-2 receptor and are thought to be important factors
in vascular maturation and stability during angiogenesis. In this study, we investigated the
expression of Ang-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) in
surgically resected specimens from 46 patients with HCC to determine their potential role in …
underlying the process of angiogenesis are not fully understood. Angiopoietins (Ang) have
been recently identified as ligands for Tie-2 receptor and are thought to be important factors
in vascular maturation and stability during angiogenesis. In this study, we investigated the
expression of Ang-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) in
surgically resected specimens from 46 patients with HCC to determine their potential role in …