Biochemistry and molecular cell biology of diabetic complications

M Brownlee - Nature, 2001 - nature.com
M Brownlee
Nature, 2001nature.com
Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and
nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of
myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have
been implicated in glucose-mediated vascular damage. All seem to reflect a single
hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial
electron-transport chain. This integrating paradigm provides a new conceptual framework for …
Abstract
Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.
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