Uremia accelerates both atherosclerosis and arterial calcification in apolipoprotein E knockout mice
ZA Massy, O Ivanovski, T Nguyen-Khoa… - Journal of the …, 2005 - journals.lww.com
Chronic renal failure (CRF) favors the development of atherosclerosis and excessive
calcification of atheromatous lesions. CRF was induced in apolipoprotein E knockout
(apoE−/−) mice to study (1) a possible acceleration of aortic atherosclerosis,(2) the degree
and type of vascular calcification, and (3) factors involved in the calcification process. For
creating CRF, 8-wk-old apolipoprotein E gene knockout (apoE−/−) mice underwent partial
kidney ablation. Control animals underwent sham operation. Aortic atherosclerotic plaques …
calcification of atheromatous lesions. CRF was induced in apolipoprotein E knockout
(apoE−/−) mice to study (1) a possible acceleration of aortic atherosclerosis,(2) the degree
and type of vascular calcification, and (3) factors involved in the calcification process. For
creating CRF, 8-wk-old apolipoprotein E gene knockout (apoE−/−) mice underwent partial
kidney ablation. Control animals underwent sham operation. Aortic atherosclerotic plaques …