Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells
Nature biotechnology, 2004•nature.com
Identification of biomaterials that support appropriate cellular attachment, proliferation and
gene expression patterns is critical for tissue engineering and cell therapy. Here we
describe an approach for rapid, nanoliter-scale synthesis of biomaterials and
characterization of their interactions with cells. We simultaneously characterize over 1,700
human embryonic stem cell–material interactions and identify a host of unexpected
materials effects that offer new levels of control over human embryonic stem cell behavior.
gene expression patterns is critical for tissue engineering and cell therapy. Here we
describe an approach for rapid, nanoliter-scale synthesis of biomaterials and
characterization of their interactions with cells. We simultaneously characterize over 1,700
human embryonic stem cell–material interactions and identify a host of unexpected
materials effects that offer new levels of control over human embryonic stem cell behavior.
Abstract
Identification of biomaterials that support appropriate cellular attachment, proliferation and gene expression patterns is critical for tissue engineering and cell therapy. Here we describe an approach for rapid, nanoliter-scale synthesis of biomaterials and characterization of their interactions with cells. We simultaneously characterize over 1,700 human embryonic stem cell–material interactions and identify a host of unexpected materials effects that offer new levels of control over human embryonic stem cell behavior.
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