Elderly people insidiously manifest the symptoms of heart failure, such as dyspnea and/or
physical disabilities in an age-dependent manner. Although previous studies suggested that
oxidative stress plays a pathological role in the development of heart failure, no direct
evidence has been documented so far. In order to investigate the pathological significance
of oxidative stress in the heart, we generated heart/muscle-specific manganese superoxide
dismutase-deficient mice. The mutant mice developed progressive congestive heart failure …