Mining incretin hormone pathways for novel therapies

RD Wideman, TJ Kieffer - Trends in Endocrinology & Metabolism, 2009 - cell.com
RD Wideman, TJ Kieffer
Trends in Endocrinology & Metabolism, 2009cell.com
The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-
like peptide-1 (GLP-1), are produced predominantly by enteroendocrine cells and have
multiple blood glucose-lowering effects. Recent years have seen a surge of interest in
understanding the basic physiology and pathophysiology of incretins and in applying this
knowledge to the treatment of diabetes and obesity. Considerable gains have been made in
elucidating the mechanisms controlling incretin secretion, and there is growing evidence to …
The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are produced predominantly by enteroendocrine cells and have multiple blood glucose-lowering effects. Recent years have seen a surge of interest in understanding the basic physiology and pathophysiology of incretins and in applying this knowledge to the treatment of diabetes and obesity. Considerable gains have been made in elucidating the mechanisms controlling incretin secretion, and there is growing evidence to suggest that incretins might be involved in the rapid reversal of diabetes observed in gastric bypass patients. Here, we review these recent advances and outline the multiple strategies being pursued to exploit the potential therapeutic benefits of GIP and GLP-1.
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