Interleukin-17 family and IL-17 receptors

TA Moseley, DR Haudenschild, L Rose… - Cytokine & growth factor …, 2003 - Elsevier
Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently
discovered related molecules are forming a family of cytokines, the IL-17 family. The
prototype member of the family has been designated IL-17A. Due to recent advances in the
human genome sequencing and proteomics five additional members have been identified
and cloned: IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The cognate receptors for the IL-17
family identified thus far are: IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL …