[HTML][HTML] Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells
E Gonzalez, R Kou, T Michel - Journal of Biological Chemistry, 2006 - ASBMB
Sphingosine 1-phosphate (S1P) is a platelet-derived sphingolipid that activates G protein-
coupled S1P receptors and initiates a broad range of responses in vascular endothelial
cells. The small GTPase Rac1 is implicated in diverse S1P-modulated cellular responses in
endothelial cells, yet the molecular mechanisms involved in S1P-mediated Rac1 activation
are incompletely understood. We studied the pathways involved in S1P-mediated Rac1
activation in bovine aortic endothelial cells (BAEC) and found that S1P-induced Rac1 …
coupled S1P receptors and initiates a broad range of responses in vascular endothelial
cells. The small GTPase Rac1 is implicated in diverse S1P-modulated cellular responses in
endothelial cells, yet the molecular mechanisms involved in S1P-mediated Rac1 activation
are incompletely understood. We studied the pathways involved in S1P-mediated Rac1
activation in bovine aortic endothelial cells (BAEC) and found that S1P-induced Rac1 …