New functions for the matrix metalloproteinases in cancer progression
Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and
metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with
disappointing results. We now know, however, that the MMPs have functions other than
promotion of invasion, have substrates other than components of the extracellular matrix,
and that they function before invasion in the development of cancer. With this knowledge in
hand, can we rethink the use of MMP inhibitors in the clinic?
metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with
disappointing results. We now know, however, that the MMPs have functions other than
promotion of invasion, have substrates other than components of the extracellular matrix,
and that they function before invasion in the development of cancer. With this knowledge in
hand, can we rethink the use of MMP inhibitors in the clinic?
Abstract
Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with disappointing results. We now know, however, that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer. With this knowledge in hand, can we rethink the use of MMP inhibitors in the clinic?
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