[HTML][HTML] E3 ubiquitin ligase Smurf1 mediates core-binding factor α1/Runx2 degradation and plays a specific role in osteoblast differentiation
M Zhao, M Qiao, BO Oyajobi, GR Mundy… - Journal of Biological …, 2003 - ASBMB
Osteoblast differentiation and bone formation is stimulated by bone morphogenetic protein
(BMP)-2 and its downstream signaling molecules Smad1 and-5 and the osteoblast-specific
transcription factor core-binding factor α1 (Cbfa1). Proteolytic degradation of Smad1 and
Cbfa1 is proteasome-dependent, and intracellular concentrations of Smad1 and Cbfa1 are
enhanced by inhibition of the 26 S proteasome. Smad1 degradation is mediated by the E3
ubiquitin ligase Smurf1 (Smad ubiquitin regulatory factor 1), but the specific E3 ligase …
(BMP)-2 and its downstream signaling molecules Smad1 and-5 and the osteoblast-specific
transcription factor core-binding factor α1 (Cbfa1). Proteolytic degradation of Smad1 and
Cbfa1 is proteasome-dependent, and intracellular concentrations of Smad1 and Cbfa1 are
enhanced by inhibition of the 26 S proteasome. Smad1 degradation is mediated by the E3
ubiquitin ligase Smurf1 (Smad ubiquitin regulatory factor 1), but the specific E3 ligase …