[HTML][HTML] Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor (MIF) in human dermal fibroblasts
H Watanabe, T Shimizu, J Nishihira, R Abe… - Journal of Biological …, 2004 - ASBMB
Matrix metalloproteinases (MMPs) are thought to be responsible for dermal photoaging in
human skin. In the present study, we evaluated the involvement of macrophage migration
inhibitory factor (MIF) in MMP-1 expression under ultraviolet A (UVA) irradiation in cultured
human dermal fibroblasts. UVA (20 J/cm 2) up-regulates MIF production, and UVA-induced
MMP-1 mRNA production is inhibited by an anti-MIF antibody. MIF (100 ng/ml) was shown to
induce MMP-1 in cultured human dermal fibroblasts. We found that MIF (100 ng/ml) …
human skin. In the present study, we evaluated the involvement of macrophage migration
inhibitory factor (MIF) in MMP-1 expression under ultraviolet A (UVA) irradiation in cultured
human dermal fibroblasts. UVA (20 J/cm 2) up-regulates MIF production, and UVA-induced
MMP-1 mRNA production is inhibited by an anti-MIF antibody. MIF (100 ng/ml) was shown to
induce MMP-1 in cultured human dermal fibroblasts. We found that MIF (100 ng/ml) …