[HTML][HTML] Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling
EW Bush, DB Hood, PJ Papst, JA Chapo… - Journal of Biological …, 2006 - ASBMB
The calcium/calmodulin-dependent phosphatase calcineurin plays a central role in the
control of cardiomyocyte hypertrophy in response to pathological stimuli. Although
calcineurin is present at high levels in normal heart, its activity appears to be unaffected by
calcium during the course of a cardiac cycle. The mechanism (1212125) whereby
calcineurin is selectively activated by calcium under pathological conditions has remained
unclear. Here, we demonstrate that diverse signals for cardiac hypertrophy stimulate …
control of cardiomyocyte hypertrophy in response to pathological stimuli. Although
calcineurin is present at high levels in normal heart, its activity appears to be unaffected by
calcium during the course of a cardiac cycle. The mechanism (1212125) whereby
calcineurin is selectively activated by calcium under pathological conditions has remained
unclear. Here, we demonstrate that diverse signals for cardiac hypertrophy stimulate …