Acute LPS inhalation in healthy volunteers induces dendritic cell maturation in vivo

NE Alexis, JC Lay, M Almond, PA Bromberg… - Journal of Allergy and …, 2005 - Elsevier
BACKGROUND: We have been studying the innate immune response of airways cells of
healthy human volunteers to inhaled LPS, a Toll-like receptor 4 (TLR4) ligand, and have
shown that macrophage phagocytic capacity is blunted. OBJECTIVE: Because a primary
feature of dendritic cell (DC) maturation is a loss of phagocytic capacity, we sought to
determine whether acute LPS inhalation in healthy volunteers promotes DC maturation in
vivo. METHODS: Phagocytosis (IgG-opsonized zymosan particles) and cell-surface …