Quantifying the infectivity of human immunodeficiency virus.
SP Layne, JL Spouge… - Proceedings of the …, 1989 - National Acad Sciences
Proceedings of the National Academy of Sciences, 1989•National Acad Sciences
We have developed a mathematical model that quantifies lymphocyte infection by human
immunodeficiency virus (HIV) and lymphocyte protection by blocking agents such as soluble
CD4. We use this model to suggest standardized parameters for quantifying viral infectivity
and to suggest techniques for calculating these parameters from well-mixed infectivity
assays. We discuss the implications of the model for our understanding of the infectious
process and virulence of HIV in vivo.
immunodeficiency virus (HIV) and lymphocyte protection by blocking agents such as soluble
CD4. We use this model to suggest standardized parameters for quantifying viral infectivity
and to suggest techniques for calculating these parameters from well-mixed infectivity
assays. We discuss the implications of the model for our understanding of the infectious
process and virulence of HIV in vivo.
We have developed a mathematical model that quantifies lymphocyte infection by human immunodeficiency virus (HIV) and lymphocyte protection by blocking agents such as soluble CD4. We use this model to suggest standardized parameters for quantifying viral infectivity and to suggest techniques for calculating these parameters from well-mixed infectivity assays. We discuss the implications of the model for our understanding of the infectious process and virulence of HIV in vivo.
National Acad Sciences