Phosducin is a photoreceptor-specific protein known to interact with the βγ subunits of G
proteins. In pursuit of the function of phosducin, we tested the hypothesis that it regulates the
light-driven translocation of G protein transducin from the outer segments of rod
photoreceptors to other compartments of the rod cell. Transducin translocation has been
previously shown to contribute to rod adaptation to bright illumination, yet the molecular
mechanisms underlying the translocation phenomenon remain unknown. In this study we …