[HTML][HTML] The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock*♦
Caspase-1 is an essential effector of inflammation, pyroptosis, and septic shock. Few
caspase-1 substrates have been identified to date, and these substrates do not account for
its wide range of actions. To understand the function of caspase-1, we initiated the
systematic identification of its cellular substrates. Using the diagonal gel proteomic
approach, we identified 41 proteins that are directly cleaved by caspase-1. Among these
were chaperones, cytoskeletal and translation machinery proteins, and proteins involved in …
caspase-1 substrates have been identified to date, and these substrates do not account for
its wide range of actions. To understand the function of caspase-1, we initiated the
systematic identification of its cellular substrates. Using the diagonal gel proteomic
approach, we identified 41 proteins that are directly cleaved by caspase-1. Among these
were chaperones, cytoskeletal and translation machinery proteins, and proteins involved in …