[HTML][HTML] Interleukin-33 is biologically active independently of caspase-1 cleavage
D Talabot-Ayer, C Lamacchia, C Gabay… - Journal of Biological …, 2009 - ASBMB
The new interleukin (IL)-1 family cytokine IL-33 is synthesized as a 30-kDa precursor. Like
pro-IL-1β, human pro-IL-33 was reported to be cleaved by caspase-1 to generate an 18-kDa
fragment, which is sufficient to activate signaling by the IL-33 receptor T1/ST2. However, the
proposed caspase-1 cleavage site is poorly conserved between species. In addition, it is not
clear whether caspase-1 cleavage of pro-IL-33 occurs in vivo and whether, as for IL-1β, this
cleavage is a prerequisite for IL-33 secretion and bioactivity. In this study, we further …
pro-IL-1β, human pro-IL-33 was reported to be cleaved by caspase-1 to generate an 18-kDa
fragment, which is sufficient to activate signaling by the IL-33 receptor T1/ST2. However, the
proposed caspase-1 cleavage site is poorly conserved between species. In addition, it is not
clear whether caspase-1 cleavage of pro-IL-33 occurs in vivo and whether, as for IL-1β, this
cleavage is a prerequisite for IL-33 secretion and bioactivity. In this study, we further …