[HTML][HTML] Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells: roles in cell injury processes of pancreatitis
AS Gukovskaya, I Gukovsky, Y Jung, M Mouria… - Journal of Biological …, 2002 - ASBMB
Apoptosis and necrosis are critical parameters of pancreatitis, the mechanisms of which
remain unknown. Many characteristics of pancreatitis can be studied in vitro in pancreatic
acini treated with high doses of cholecystokinin (CCK). We show here that CCK stimulates
apoptosis and death signaling pathways in rat pancreatic acinar cells, including caspase
activation, cytochromec release, and mitochondrial depolarization. The mitochondrial
dysfunction is mediated by upstream caspases (possibly caspase-8) and, in turn, leads to …
remain unknown. Many characteristics of pancreatitis can be studied in vitro in pancreatic
acini treated with high doses of cholecystokinin (CCK). We show here that CCK stimulates
apoptosis and death signaling pathways in rat pancreatic acinar cells, including caspase
activation, cytochromec release, and mitochondrial depolarization. The mitochondrial
dysfunction is mediated by upstream caspases (possibly caspase-8) and, in turn, leads to …