[HTML][HTML] Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo
W Xiong, R Knispel, J MacTaggart, TC Greiner… - Journal of biological …, 2009 - ASBMB
During arterial aneurysm formation, levels of the membrane-anchored matrix
metalloproteinase, MT1-MMP, are elevated dramatically. Although MT1-MMP is expressed
predominately by infiltrating macrophages, the roles played by the proteinase in abdominal
aortic aneurysm (AAA) formation in vivo remain undefined. Using a newly developed
chimeric mouse model of AAA, we now demonstrate that macrophage-derived MT1-MMP
plays a dominant role in disease progression. In wild-type mice transplanted with MT1-MMP …
metalloproteinase, MT1-MMP, are elevated dramatically. Although MT1-MMP is expressed
predominately by infiltrating macrophages, the roles played by the proteinase in abdominal
aortic aneurysm (AAA) formation in vivo remain undefined. Using a newly developed
chimeric mouse model of AAA, we now demonstrate that macrophage-derived MT1-MMP
plays a dominant role in disease progression. In wild-type mice transplanted with MT1-MMP …