Iron chelation in rheumatoid arthritis: clinical and laboratory evaluation.
M Magaro, A Zoli, L Altomonte, L Mirone… - Annals of the …, 1990 - ncbi.nlm.nih.gov
M Magaro, A Zoli, L Altomonte, L Mirone, G Corvino, S Storti, R Marra, BM Ricerca…
Annals of the rheumatic diseases, 1990•ncbi.nlm.nih.govSplinter haemorrhages in systemic lupus erythematosus were first reported in 1% 6 by Fraga
and Mintz5 and were the subject of a recent review by Young et al. 6 Although larger
vascular occlusions are more commonly associated with antiphospholipid antibodies, 7
smaller size vessels, such as the retinal'or digital or pedal vasculature, with the resultant
ischaemic complications of infarctions and gangrene, have been reported. 9 These lesions
have been unassociated with vasculitis. The presence of subungual splinter haemorrhages …
and Mintz5 and were the subject of a recent review by Young et al. 6 Although larger
vascular occlusions are more commonly associated with antiphospholipid antibodies, 7
smaller size vessels, such as the retinal'or digital or pedal vasculature, with the resultant
ischaemic complications of infarctions and gangrene, have been reported. 9 These lesions
have been unassociated with vasculitis. The presence of subungual splinter haemorrhages …
Splinter haemorrhages in systemic lupus erythematosus were first reported in 1% 6 by Fraga and Mintz5 and were the subject of a recent review by Young et al. 6 Although larger vascular occlusions are more commonly associated with antiphospholipid antibodies, 7 smaller size vessels, such as the retinal'or digital or pedal vasculature, with the resultant ischaemic complications of infarctions and gangrene, have been reported. 9 These lesions have been unassociated with vasculitis.
The presence of subungual splinter haemorrhages may similarly represent evidence of platelet thrombi in the smaller vessels to the nail bed in patients with the'antiphospholipid syndrome'. A similar mechanism may be causing the transient ischaemic attacks. I wish to drawattention to the presence of this sign and to emphasise the importance of careful examination of this group of patients in order to increase its detection.
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