Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications
S Huang - Clinical Cancer Research, 2007 - AACR
S Huang
Clinical Cancer Research, 2007•AACRNumerous cytokines, growth factors, and oncogenic proteins activate signal transducer and
activator of transcription 3 (Stat3), which has been recognized as one of the common
pathways in cancer cells. Stat3 signaling affects the expression and function of a variety of
genes that are critical to cell survival, cell proliferation, invasion, angiogenesis, and immune
evasion. Evidently, the Stat3 signaling pathway regulates cancer metastasis and constitutes
a potential preventive and therapeutic target for cancer metastasis.
activator of transcription 3 (Stat3), which has been recognized as one of the common
pathways in cancer cells. Stat3 signaling affects the expression and function of a variety of
genes that are critical to cell survival, cell proliferation, invasion, angiogenesis, and immune
evasion. Evidently, the Stat3 signaling pathway regulates cancer metastasis and constitutes
a potential preventive and therapeutic target for cancer metastasis.
Abstract
Numerous cytokines, growth factors, and oncogenic proteins activate signal transducer and activator of transcription 3 (Stat3), which has been recognized as one of the common pathways in cancer cells. Stat3 signaling affects the expression and function of a variety of genes that are critical to cell survival, cell proliferation, invasion, angiogenesis, and immune evasion. Evidently, the Stat3 signaling pathway regulates cancer metastasis and constitutes a potential preventive and therapeutic target for cancer metastasis.
AACR