Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial dysfunction
TN Abahji, L Nill, N Ide, C Keller, U Hoffmann… - Archives of medical …, 2007 - Elsevier
BACKGROUND: Hyperhomocysteinemia (Hhcy) has been shown to induce endothelial
dysfunction due to a decrease in bioavailable nitric oxide (NO) by increased vascular
oxidant stress. This can be detected as an impairment of endothelium-dependent
vasodilation in conductance arteries, like brachial or coronary arteries. The effect of Hhcy on
endothelial function (EF) in small resistance vessels that critically determine organ
perfusion, however, has not been studied systematically in humans. Therefore, we …
dysfunction due to a decrease in bioavailable nitric oxide (NO) by increased vascular
oxidant stress. This can be detected as an impairment of endothelium-dependent
vasodilation in conductance arteries, like brachial or coronary arteries. The effect of Hhcy on
endothelial function (EF) in small resistance vessels that critically determine organ
perfusion, however, has not been studied systematically in humans. Therefore, we …