[HTML][HTML] Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1
Y Wang, JM Schattenberg, RM Rigoli, P Storz… - Journal of Biological …, 2004 - ASBMB
The prevention of injury from reactive oxygen species is critical for cellular resistance to
many death stimuli. Resistance to death from the superoxide generator menadione in the
hepatocyte cell line RALA255–10G is dependent on down-regulation of the c-Jun N-terminal
kinase (JNK)/AP-1 signaling pathway by extracellular signal-regulated kinase 1/2 (ERK1/2).
Because protein kinase C (PKC) regulates both oxidant stress and JNK signaling, the ability
of PKC to modulate hepatocyte death from menadione through effects on AP-1 was …
many death stimuli. Resistance to death from the superoxide generator menadione in the
hepatocyte cell line RALA255–10G is dependent on down-regulation of the c-Jun N-terminal
kinase (JNK)/AP-1 signaling pathway by extracellular signal-regulated kinase 1/2 (ERK1/2).
Because protein kinase C (PKC) regulates both oxidant stress and JNK signaling, the ability
of PKC to modulate hepatocyte death from menadione through effects on AP-1 was …