Dopachrome tautomerase decreases the binding of indolic melanogenesis intermediates to proteins
C Salinas, JC García-Borrón, F Solano… - Biochimica et Biophysica …, 1994 - Elsevier
Dopachrome tautomerase (DCT) is a recently characterized enzyme contributing to the
control of melanogenesis in mammals. The enzyme catalyzes the rearrangement of l-
Dopachrome (l-DC) to 5, 6-dihydroxyindole 2-carboxylic acid (DHICA), while the
spontaneous rearrangement of l-DC leads to 5, 6-dihydroxyindole (DHI). Due to the lower
reactivity of DHICA in comparison to DHI, DCT could provide a protective mechanism
against the cytotoxicity of decarboxylated indolic melanogenic intermediates by limiting the …
control of melanogenesis in mammals. The enzyme catalyzes the rearrangement of l-
Dopachrome (l-DC) to 5, 6-dihydroxyindole 2-carboxylic acid (DHICA), while the
spontaneous rearrangement of l-DC leads to 5, 6-dihydroxyindole (DHI). Due to the lower
reactivity of DHICA in comparison to DHI, DCT could provide a protective mechanism
against the cytotoxicity of decarboxylated indolic melanogenic intermediates by limiting the …