The Protein C pathway plays a crucial role in the regulation of thrombosis and inflammation.
One of the tools that researchers presently use to elucidate mechanisms of action of
activated protein C (APC) is the use of transgenic or gene deletion murine models. To
correlate observations in these murine models with the APC levels, there is a need for a
sensitive and specific assay for circulating murine APC in plasma. We developed an
immunological assay to measure the physiological and pharmacologic levels of circulating …