Decrease of CD56+ T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma
N Kawarabayashi, S Seki, K Hatsuse, T Ohkawa… - Hepatology, 2000 - Elsevier
Abstract CD56+ T cells and CD56+ natural killer (NK) cells are abundant in the human liver.
The aim of this study was the further characterization of these cells in the liver with or without
hepatitis C virus (HCV) infection. Liver mononuclear cells (MNC) were isolated from liver
specimens obtained from the patients during abdominal surgery. In addition to a flow
cytometric analysis, liver MNC and PBMC were cultured with the immobilized anti-CD3 Ab,
IL-2, or a combination of IL-2 and IL-12 and their IFN-γ production and the antitumor …
The aim of this study was the further characterization of these cells in the liver with or without
hepatitis C virus (HCV) infection. Liver mononuclear cells (MNC) were isolated from liver
specimens obtained from the patients during abdominal surgery. In addition to a flow
cytometric analysis, liver MNC and PBMC were cultured with the immobilized anti-CD3 Ab,
IL-2, or a combination of IL-2 and IL-12 and their IFN-γ production and the antitumor …