Hepatic lipase mediates the uptake of chylomicrons and beta-VLDL into cells via the LDL receptor-related protein (LRP)
A Krapp, S Ahle, S Kersting, Y Hua, K Kneser… - Journal of lipid …, 1996 - ASBMB
The uptake of triglyceride-rich lipoproteins has been described as being mediated by
apolipoprotein E and lipoprotein lipase (LpL). Proteoglycans, the LDL-receptor, and the LDL
receptor-related protein (LRP) are the cellular acceptors. In addition to LpL, hepatic lipase
(HL) has been shown to bind to LRP. In this study, the role of HL in lipoprotein uptake was
investigated. Human chylomicrons and rabbit beta-VLDL were used as ligands for human
hepatoma cells, primary human hepalocytes, normal and proteoglycan-deficient Chinese …
apolipoprotein E and lipoprotein lipase (LpL). Proteoglycans, the LDL-receptor, and the LDL
receptor-related protein (LRP) are the cellular acceptors. In addition to LpL, hepatic lipase
(HL) has been shown to bind to LRP. In this study, the role of HL in lipoprotein uptake was
investigated. Human chylomicrons and rabbit beta-VLDL were used as ligands for human
hepatoma cells, primary human hepalocytes, normal and proteoglycan-deficient Chinese …