Because increasing evidence implicates heparan sulfate proteoglycans (HSPGs) as
essential cofactors in receptor-growth factor interactions, in cell-cell recognition systems,
and in cell-matrix adhesion processes and yet little is known about their cellular distribution
pattern and cellular sources in liver tissue, we used monoclonal antibodies specific for the
core proteins of syndecan1, 2, 3, 4, glypican, and perlecan to investigate their
immunohistochemical expression in normal adult human liver biopsy specimens. Syndecanl …