[HTML][HTML] The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits
P Michaely, WP Li, RGW Anderson, JC Cohen… - Journal of Biological …, 2004 - ASBMB
ARH is an adaptor protein required for efficient endocytosis of low density lipoprotein (LDL)
receptors (LDLRs) in selected tissues. Individuals lacking ARH (ARH-/-) have severe
hypercholesterolemia due to impaired hepatic clearance of LDL. Immortalized lymphocytes,
but not fibroblasts, from ARH-deficient subjects fail to internalize LDL. To further define the
role of ARH in LDLR function, we compared the subcellular distribution of the LDLR in
lymphocytes from normal and ARH-/-subjects. In normal lymphocytes LDLRs were …
receptors (LDLRs) in selected tissues. Individuals lacking ARH (ARH-/-) have severe
hypercholesterolemia due to impaired hepatic clearance of LDL. Immortalized lymphocytes,
but not fibroblasts, from ARH-deficient subjects fail to internalize LDL. To further define the
role of ARH in LDLR function, we compared the subcellular distribution of the LDLR in
lymphocytes from normal and ARH-/-subjects. In normal lymphocytes LDLRs were …