[HTML][HTML] SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6
SOX9 is a transcription factor that plays a key role in chondrogenesis. Aggrecan is one of the
major structural components in cartilage; however, the molecular mechanism of aggrecan
gene regulation has not yet been fully elucidated. TC6 is a clonal chondrocytic cell line
derived from articular cartilage. The purpose of this study was to examine whether SOX9
modulates aggrecan gene expression and to further identify molecules that regulateSox9
expression in TC6 cells. SOX9 overexpression in TC6 cells enhanced by∼ 3-fold the …
major structural components in cartilage; however, the molecular mechanism of aggrecan
gene regulation has not yet been fully elucidated. TC6 is a clonal chondrocytic cell line
derived from articular cartilage. The purpose of this study was to examine whether SOX9
modulates aggrecan gene expression and to further identify molecules that regulateSox9
expression in TC6 cells. SOX9 overexpression in TC6 cells enhanced by∼ 3-fold the …