[HTML][HTML] Cdk4 is indispensable for postnatal proliferation of the anterior pituitary
S Jirawatnotai, A Aziyu, EC Osmundson… - Journal of Biological …, 2004 - ASBMB
For proper development and tissue homeostasis, cell cycle progression is controlled by
multilayered mechanisms. Recent studies using knock-out mice have shown that animals
can develop relatively normally with deficiency for each of the G 1/S-regulatory proteins, D-
type and E-type cyclins, cyclin-dependent kinase 4 (Cdk4), and Cdk2. Although Cdk4-null
mice show no embryonic lethality, they exhibit specific endocrine phenotypes, ie dwarfism,
infertility, and diabetes. Here we have demonstrated that Cdk4 plays an essential non …
multilayered mechanisms. Recent studies using knock-out mice have shown that animals
can develop relatively normally with deficiency for each of the G 1/S-regulatory proteins, D-
type and E-type cyclins, cyclin-dependent kinase 4 (Cdk4), and Cdk2. Although Cdk4-null
mice show no embryonic lethality, they exhibit specific endocrine phenotypes, ie dwarfism,
infertility, and diabetes. Here we have demonstrated that Cdk4 plays an essential non …