A distinct expression of CC chemokines by macrophages in nasopharyngeal carcinoma: implication for the intense tumor infiltration by T lymphocytes and …
KF Tang, SY Tan, SH Chan, SM Chong, KS Loh… - Human pathology, 2001 - Elsevier
Nasopharyngeal carcinoma (NPC) is characterized by harboring Epstein-Barr virus genes in
the tumor cells and an intense infiltration of leukocytes in the tumor tissue. These infiltrating
cells are mainly composed of T lymphocytes and macrophages. The mechanism of this
intense infiltration has long been a puzzle. We attempted to address this issue by studying
the expression of CC chemokines, which are responsible for recruiting both T cells and
macrophages, by an immunohistochemical approach. In biopsies obtained from …
the tumor cells and an intense infiltration of leukocytes in the tumor tissue. These infiltrating
cells are mainly composed of T lymphocytes and macrophages. The mechanism of this
intense infiltration has long been a puzzle. We attempted to address this issue by studying
the expression of CC chemokines, which are responsible for recruiting both T cells and
macrophages, by an immunohistochemical approach. In biopsies obtained from …