[HTML][HTML] Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of α-synuclein

KE Paleologou, AW Schmid, CC Rospigliosi… - Journal of Biological …, 2008 - ASBMB
α-Synuclein (α-syn) phosphorylation at serine 129 is characteristic of Parkinson disease
(PD) and related α-synulceinopathies. However, whether phosphorylation promotes or
inhibits α-syn aggregation and neurotoxicity in vivo remains unknown. This understanding is
critical for elucidating the role of α-syn in the pathogenesis of PD and for development of
therapeutic strategies for PD. To better understand the structural and molecular
consequences of Ser-129 phosphorylation, we compared the biochemical, structural, and …