[HTML][HTML] FKBP12 is a negative regulator of transforming growth factor-β receptor internalization
D Yao, JJE Doré, EB Leof - Journal of Biological Chemistry, 2000 - ASBMB
Transforming growth factor-β (TGF-β) family polypeptides regulate cell growth and
differentiation by binding to single pass serine/threonine kinases referred to as TGF-β type I
and II receptors. Although interaction screens have shown that the immunophilin FKBP12
interacts with TGF-β type I receptors, the role of FKBP12 in TGF-β receptor action is
presently unclear. Using a chimeric TGF-β receptor system, we have shown a specific
enhancement of internalization when FKBP12 binding to the type I receptor was prevented …
differentiation by binding to single pass serine/threonine kinases referred to as TGF-β type I
and II receptors. Although interaction screens have shown that the immunophilin FKBP12
interacts with TGF-β type I receptors, the role of FKBP12 in TGF-β receptor action is
presently unclear. Using a chimeric TGF-β receptor system, we have shown a specific
enhancement of internalization when FKBP12 binding to the type I receptor was prevented …