[PDF][PDF] Prediction of breast tumor progression by integrity of free circulating DNA in serum
N Umetani, AE Giuliano, SH Hiramatsu… - Journal of clinical …, 2006 - academia.edu
N Umetani, AE Giuliano, SH Hiramatsu, F Amersi, T Nakagawa, S Martino, DSB Hoon
Journal of clinical oncology, 2006•academia.eduPurpose Cell-free DNA circulating in serum is a candidate molecular biomarker for
malignant tumors. Unlike uniformly truncated DNA released from apoptotic cells, DNA
released from dead cancer cells varies in size. Serum DNA integrity, the ratio of longer
fragments to total DNA, may be clinically useful for detecting breast cancer progression.
malignant tumors. Unlike uniformly truncated DNA released from apoptotic cells, DNA
released from dead cancer cells varies in size. Serum DNA integrity, the ratio of longer
fragments to total DNA, may be clinically useful for detecting breast cancer progression.
Purpose
Cell-free DNA circulating in serum is a candidate molecular biomarker for malignant tumors. Unlike uniformly truncated DNA released from apoptotic cells, DNA released from dead cancer cells varies in size. Serum DNA integrity, the ratio of longer fragments to total DNA, may be clinically useful for detecting breast cancer progression.
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