[PDF][PDF] The effects of anti-idiotypic antibody on antibody production and apoptosis of anti-dsDNA antibody producing cells
CH Lee, CH Suh, J Lee, YT Kim… - Clinical and …, 2003 - clinexprheumatol.org
CH Lee, CH Suh, J Lee, YT Kim, SK Lee
Clinical and experimental rheumatology, 2003•clinexprheumatol.orgObjective Systemic lupus erythematosus is an autoimmune disease characterized by the
production of anti-dsDNA antibody. Because the titer of anti-dsDNA antibody is correlated
with disease severity, especially in lupus nephritis, controlling anti-dsDNA antibody
production is important in the treatment of SLE. There are many regulatory mechanisms of
autoantibody production; one of these is the interaction between idiotype and anti-idiotype
antibody (anti-Id). The purpose of the present study was to assess the effect of anti-Id on anti …
production of anti-dsDNA antibody. Because the titer of anti-dsDNA antibody is correlated
with disease severity, especially in lupus nephritis, controlling anti-dsDNA antibody
production is important in the treatment of SLE. There are many regulatory mechanisms of
autoantibody production; one of these is the interaction between idiotype and anti-idiotype
antibody (anti-Id). The purpose of the present study was to assess the effect of anti-Id on anti …
Objective
Systemic lupus erythematosus is an autoimmune disease characterized by the production of anti-dsDNA antibody. Because the titer of anti-dsDNA antibody is correlated with disease severity, especially in lupus nephritis, controlling anti-dsDNA antibody production is important in the treatment of SLE. There are many regulatory mechanisms of autoantibody production; one of these is the interaction between idiotype and anti-idiotype antibody (anti-Id). The purpose of the present study was to assess the effect of anti-Id on anti-dsDNA antibody production and apoptosis and to study the mechanism of anti-Id induced apoptosis.
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