Inflammation after axonal injury has conflicting consequences for recovery of function: rescue of spared axons is impaired but regeneration is supported
DL Hirschberg, E Yoles, M Belkin… - Journal of …, 1994 - Elsevier
Neural injury leads to tissue damage beyond that caused by the initial lesion, mainly as a
result of a chain of autodestructive events triggered by the trauma. These events apparently
include the activation of immune-derived cells and their products, as treatment with anti-
inflammatory agents, such as corticosteroids, limits the damage and thus improves recovery.
On the other hand, immune-derived substances, such as cytokines, are thought to play an
important role in post-traumatic axonal regeneration. Thus, the need to reduce inflammation …
result of a chain of autodestructive events triggered by the trauma. These events apparently
include the activation of immune-derived cells and their products, as treatment with anti-
inflammatory agents, such as corticosteroids, limits the damage and thus improves recovery.
On the other hand, immune-derived substances, such as cytokines, are thought to play an
important role in post-traumatic axonal regeneration. Thus, the need to reduce inflammation …