T cell responses to myelin basic protein in patients with spinal cord injury and multiple sclerosis
K Kil, YCQ Zang, D Yang, J Markowski… - Journal of …, 1999 - Elsevier
Autoimmune inflammation secondary to myelin destruction may play an inhibitory role in
restoration of nerve functions in spinal cord injury (SCI). In this study, we demonstrated that T
cells recognizing myelin basic protein (MBP) occurred at a high precursor frequency in
patients with SCI, which was compatible to that in patients with multiple sclerosis (MS), a
disease of presumed autoimmune pathology. The findings suggest of hyperactivity of MBP-
reactive T cells in patients with SCI. MBP-reactive T cell lines derived from patients with SCI …
restoration of nerve functions in spinal cord injury (SCI). In this study, we demonstrated that T
cells recognizing myelin basic protein (MBP) occurred at a high precursor frequency in
patients with SCI, which was compatible to that in patients with multiple sclerosis (MS), a
disease of presumed autoimmune pathology. The findings suggest of hyperactivity of MBP-
reactive T cells in patients with SCI. MBP-reactive T cell lines derived from patients with SCI …