[HTML][HTML] NTB-A, a new activating receptor in T cells that regulates autoimmune disease
PA Valdez, H Wang, D Seshasayee… - Journal of Biological …, 2004 - ASBMB
The CD28 co-stimulatory pathway is well established for T cell activation; however, results
from CD28-/-mice suggest the existence of additional co-stimulatory pathways. Here we
report the further characterization of a new member of the CD2 superfamily, NTB-A,
important in T cell co-stimulation. NTB-A is expressed on T cells, and its expression is up-
regulated on activated cells. Triggering of NTB-A with monoclonal antibodies in the absence
of CD28 signals leads to T cell proliferation and interferon-γ secretion but not interleukin-4 …
from CD28-/-mice suggest the existence of additional co-stimulatory pathways. Here we
report the further characterization of a new member of the CD2 superfamily, NTB-A,
important in T cell co-stimulation. NTB-A is expressed on T cells, and its expression is up-
regulated on activated cells. Triggering of NTB-A with monoclonal antibodies in the absence
of CD28 signals leads to T cell proliferation and interferon-γ secretion but not interleukin-4 …