Human CD8+ T-cell differentiation in response to viruses
RAW Van Lier, IJM Ten Berge… - Nature Reviews …, 2003 - nature.com
RAW Van Lier, IJM Ten Berge, LE Gamadia
Nature Reviews Immunology, 2003•nature.comCD8+ T cells are essential in the defence against viruses. Recently, peptide–HLA class I
tetramers have been used to study immune responses to viruses in humans. This approach
has indicated consecutive stages of human CD8+ T-cell development in acute viral infection
and has illustrated the heterogeneity of CD8+ T cells that are specific for latent viruses. Here,
we summarize these findings and discuss their significance for our understanding of antigen-
induced CD8+ T-cell maturation in humans.
tetramers have been used to study immune responses to viruses in humans. This approach
has indicated consecutive stages of human CD8+ T-cell development in acute viral infection
and has illustrated the heterogeneity of CD8+ T cells that are specific for latent viruses. Here,
we summarize these findings and discuss their significance for our understanding of antigen-
induced CD8+ T-cell maturation in humans.
Abstract
CD8+ T cells are essential in the defence against viruses. Recently, peptide–HLA class I tetramers have been used to study immune responses to viruses in humans. This approach has indicated consecutive stages of human CD8+ T-cell development in acute viral infection and has illustrated the heterogeneity of CD8+ T cells that are specific for latent viruses. Here, we summarize these findings and discuss their significance for our understanding of antigen-induced CD8+ T-cell maturation in humans.
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