[HTML][HTML] Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
S Aggarwal, N Ghilardi, MH Xie, FJ de Sauvage… - Journal of Biological …, 2003 - ASBMB
Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells.
Despite increasing evidence that high levels of IL-17 are associated with several chronic
inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis, the
regulation of its expression is not well characterized. We observe that IL-17 production is
increased in response to the recently described cytokine IL-23. We present evidence that
murine IL-23, which is produced by activated dendritic cells, acts on memory T cells …
Despite increasing evidence that high levels of IL-17 are associated with several chronic
inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis, the
regulation of its expression is not well characterized. We observe that IL-17 production is
increased in response to the recently described cytokine IL-23. We present evidence that
murine IL-23, which is produced by activated dendritic cells, acts on memory T cells …