[HTML][HTML] Estrogen receptor α mediates 17α-ethynylestradiol causing hepatotoxicity

Y Yamamoto, R Moore, HA Hess, GL Guo… - Journal of Biological …, 2006 - ASBMB
Estrogens are known to cause hepatotoxicity such as intrahepatic cholestasis in susceptible
women during pregnancy, after administration of oral contraceptives, or during
postmenopausal replacement therapy. Enterohepatic nuclear receptors including farnesoid
X receptor (FXR), pregnane X receptor (PXR), and constitutive active/androstane receptor
(CAR) are important in maintaining bile acid homeostasis and protecting the liver from bile
acid toxicity. However, no nuclear receptor has been implicated in the mechanism for …