[HTML][HTML] Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher …
JF Fortin, C Barat, Y Beauséjour, B Barbeau… - Journal of Biological …, 2004 - ASBMB
A chronic state of immune hyperactivation is a feature of human immunodeficiency virus type-
1 (HIV-1) infection. Studies on the molecular mechanisms by which HIV-1 can modulate the
activation state of T cells indicate that both Nef and Tat can alter T cell activation. However,
the vast majority of data has been obtained from experiments performed with vectors
encoding a single virus protein. We demonstrate that infection of human CD4+ T
lymphocytes with fully infectious HIV-1 leads to a hyper-responsiveness of the interleukin-2 …
1 (HIV-1) infection. Studies on the molecular mechanisms by which HIV-1 can modulate the
activation state of T cells indicate that both Nef and Tat can alter T cell activation. However,
the vast majority of data has been obtained from experiments performed with vectors
encoding a single virus protein. We demonstrate that infection of human CD4+ T
lymphocytes with fully infectious HIV-1 leads to a hyper-responsiveness of the interleukin-2 …