Mitochondria–endoplasmic reticulum choreography: structure and signaling dynamics
Mitochondria and endoplasmic reticulum (ER) have different roles in living cells but they
interact both physically and functionally. A key aspect of the mitochondria–ER relationship is
the modulation of Ca 2+ signaling during cell activation, which thus affects a variety of
physiological processes. We focus here on the molecular aspects that control the dynamics
of the organelle–organelle interaction and their relationship with Ca 2+ signals, also
discussing the consequences that these phenomena have, not only for cell physiology but …
interact both physically and functionally. A key aspect of the mitochondria–ER relationship is
the modulation of Ca 2+ signaling during cell activation, which thus affects a variety of
physiological processes. We focus here on the molecular aspects that control the dynamics
of the organelle–organelle interaction and their relationship with Ca 2+ signals, also
discussing the consequences that these phenomena have, not only for cell physiology but …
Mitochondria and endoplasmic reticulum (ER) have different roles in living cells but they interact both physically and functionally. A key aspect of the mitochondria–ER relationship is the modulation of Ca2+ signaling during cell activation, which thus affects a variety of physiological processes. We focus here on the molecular aspects that control the dynamics of the organelle–organelle interaction and their relationship with Ca2+ signals, also discussing the consequences that these phenomena have, not only for cell physiology but also in the control of cell death.
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