Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina
A Laabich, G Li, NGF Cooper - Molecular brain research, 2001 - Elsevier
Calcium/calmodulin-dependent protein kinase II containing a nuclear localizing signal
(CaMKII-αB) is altered in retinal neurons exposed to N-methyl-d-aspartate (NMDA). AIP
(myristoylated autocamtide-2-related inhibitory peptide), a specific inhibitor of CaMKII
provides neuroprotection against NMDA-mediated neurotoxicity. In this study, gene-arrays
were used to investigate which apoptosis-associated genes are altered after exposure to
NMDA. The data indicate an increased expression (2–7-fold) of five such genes encoding …
(CaMKII-αB) is altered in retinal neurons exposed to N-methyl-d-aspartate (NMDA). AIP
(myristoylated autocamtide-2-related inhibitory peptide), a specific inhibitor of CaMKII
provides neuroprotection against NMDA-mediated neurotoxicity. In this study, gene-arrays
were used to investigate which apoptosis-associated genes are altered after exposure to
NMDA. The data indicate an increased expression (2–7-fold) of five such genes encoding …
