Cyclin I: a new cyclin encoded by a gene isolated from human brain
T Nakamura, R Sanokawa, YF Sasaki… - Experimental cell …, 1995 - Elsevier
T Nakamura, R Sanokawa, YF Sasaki, D Ayusawa, M Oishi, N Mori
Experimental cell research, 1995•ElsevierA new member of the cyclin family has been isolated from an equalized cDNA library
derived from human forebrain cortex. This putative cyclin, designated cyclin I, contains a
typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. Cyclin I
shows the highest sequence similarity in the cyclin box to cyclins G and E, while the
similarity between cyclins I and G also extends toward the C-terminus from the cyclin box.
Cyclin I mRNA was expressed at high levels in postmitotic tissues, including skeletal muscle …
derived from human forebrain cortex. This putative cyclin, designated cyclin I, contains a
typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. Cyclin I
shows the highest sequence similarity in the cyclin box to cyclins G and E, while the
similarity between cyclins I and G also extends toward the C-terminus from the cyclin box.
Cyclin I mRNA was expressed at high levels in postmitotic tissues, including skeletal muscle …
A new member of the cyclin family has been isolated from an equalized cDNA library derived from human forebrain cortex. This putative cyclin, designated cyclin I, contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. Cyclin I shows the highest sequence similarity in the cyclin box to cyclins G and E, while the similarity between cyclins I and G also extends toward the C-terminus from the cyclin box. Cyclin I mRNA was expressed at high levels in postmitotic tissues, including skeletal muscle, heart, and brain, and was expressed constantly during cell cycle progression. The expression of cyclin I mRNA does not correlate directly to the cell cycle, and therefore cyclin I may be a novel cyclin member that functions independently of the cell cycle control.
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