Anti-sclerotic effect of transforming growth factor-β antibody in a mouse model of bleomycin-induced scleroderma
T Yamamoto, S Takagawa, I Katayama, K Nishioka - Clinical immunology, 1999 - Elsevier
Recent studies have demonstrated the evidence of the crucial role of transforming growth
factor-β (TGF-β) in the pathogenesis of tissue fibrosis; however, its precise role has not been
fully elucidated. Administration of anti-TGF-β antibody is shown to be effective for inhibiting
lung fibrosis induced by bleomycin in an experimental animal model. We have recently
established a mouse model for scleroderma by repeated injections of bleomycin. In this
study, we examined whether the suppression of TGF-β leads to the improvement of dermal …
factor-β (TGF-β) in the pathogenesis of tissue fibrosis; however, its precise role has not been
fully elucidated. Administration of anti-TGF-β antibody is shown to be effective for inhibiting
lung fibrosis induced by bleomycin in an experimental animal model. We have recently
established a mouse model for scleroderma by repeated injections of bleomycin. In this
study, we examined whether the suppression of TGF-β leads to the improvement of dermal …