A controlled trial of HA-1A in a canine model of gram-negative septic shock

ZMN Quezado, C Natanson, DW Ailing, SM Banks… - Jama, 1993 - jamanetwork.com
Objectvie.—To investigate the therapeutic efficacy and microbiological and physiological
effects of a human IgM monoclonal antibody (HA-1 A) directed against the lipid A component
of endotoxin in a canine model of sepsis that simulates the cardiovascular abnormalities of
human septic shock. Design.—Blinded, placebo-controlled 28-day trial. Interventions.—
Purpose-bred beagles were implanted with an intraperitoneal clot infected withEscherichia
coliO111: B4. At clot placement, animals received HA-1A (10 mg. kg-1), control human IgM …