[HTML][HTML] Shock and multiple-organ dysfunction after self-administration of Salmonella endotoxin

AMT da Silva, HC Kaulbach, FS Chuidian… - … England Journal of …, 1993 - Mass Medical Soc
AMT da Silva, HC Kaulbach, FS Chuidian, DR Lambert, AF Suffredini, RL Danner
New England Journal of Medicine, 1993Mass Medical Soc
Endotoxin, a lipopolysaccharide component of the outer membrane of gram-negative
bacteria, is involved in the pathogenesis of septic shock, but it is unclear whether endotoxin
alone is capable of causing all the manifestations of the septic shock syndrome. In animals,
endotoxin causes many of the clinical features1 but produces a low-cardiac-output form of
shock that is unlike the hyperdynamic cardiovascular profile of septic shock in humans2, 3.
In humans, the administration of endotoxin (4 ng per kilogram of body weight) triggers the …
Endotoxin, a lipopolysaccharide component of the outer membrane of gram-negative bacteria, is involved in the pathogenesis of septic shock, but it is unclear whether endotoxin alone is capable of causing all the manifestations of the septic shock syndrome. In animals, endotoxin causes many of the clinical features1 but produces a low-cardiac-output form of shock that is unlike the hyperdynamic cardiovascular profile of septic shock in humans2,3. In humans, the administration of endotoxin (4 ng per kilogram of body weight) triggers the release of cytokines,4 activates the coagulation and fibrinolytic systems,5,6 and causes a decrease in systemic vascular . . .
The New England Journal Of Medicine