The signaling lymphocytic activation molecule family of receptors has been implicated in the
pathophysiology of autoimmunity in humans and mice. One member of the family, Ly108,
was strongly linked to lupus susceptibility in mice. High expression of a Ly108 isoform,
Ly108-1, was observed in lymphocytes of lupus-prone mice. Herein, we examined the
molecular basis for the influence of Ly108 on lupus susceptibility by studying Ly108 signal
transduction in T cells. We observed that Ly108 was able to mediate a tyrosine …